TCRαβ+ Cell Deleted Versus Traditional Haploidentical Hematopoietic Stem Cell Transplantation ：A Single-center, Prospective, Non-randomized Controlled Clinical Study
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a single-center prospective, non-randomized controlled clinical study in China using CliniMACS TCRα/β+ cell depleted stem cell haploidentical donors versus conventional Beijing protocol for haploidentical hematopoietic stem cell transplantation in children.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 1 month
Maximum Age: 18
Healthy Volunteers: f
View:
• Age 8 weeks to 18 years
• Children who meet the indicators haploidentical hematopoietic cell transplantation
• No HLA ≥ 9/10 donor or not suitable for this type of donor due to illness
• Informed consent must be signed (by the patient or legal representative)
Locations
Other Locations
China
Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University
RECRUITING
Shanghai
Contact Information
Primary
Jing Chen, PhD
chenjing@scmc.com.cn
38626161
Time Frame
Start Date: 2024-05-26
Estimated Completion Date: 2028-03-31
Participants
Target number of participants: 110
Treatments
No_intervention: Traditional Haplo identicle HCT
Beijing haploidenticla HCT is the routinely traditional way used for haploidentical HCT
Experimental: TCRαβ Depleted haploidentical HCT
TCRαβ Depleted haploidentical HCT is experimental used to decrease GVHD and obtain better qulity of life for children with haploidentical HCT.
Related Therapeutic Areas
Sponsors
Leads: Sijia Gu